EFFECTS OF XINFENG CAPSULE ON LIPOPROTEIN METABOLISM IN ADJUVANT ARTHRITIS RATS BASED ON VASCULAR STRESS IMBALANCE

WAN LEI, LIU JIAN^*, HUANG CHUAN-BING, WANG YUAN, SHEN XI, ZHANG WAN-DONG, WANG GUI-ZHENG, FAN HAI-XIA, GE YAO, CHEN RUI-LIAN, CAO YUN-XIANG, ZONG RUI-KAI, LIU TIAN-YANG

Department of Rheumatology, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China

Objective: To observe the effect of Xinfeng Capsule (XFC) on protein metabolism and cytokines in adjuvant arthritis (AA).

Methods: 60 rats were randomly divided into normal control group (NC) group, model control group (MC) group, methotrexa- te (MTX), tripterygium wilfordii polyglycoside (TPT) group and XFC group. To the rats except the NC group, the right hind foot plantar intradermal injection of 0.1ml inflammation. / G), apolipoprotein A1 (Apo-A1), Apolipoprotein B (Apo-B), apolipoprotein A1 / B (APOA1 / B), cytokines, GMP-140, CD40L were observed after 30 days of administration.

Results: Compared with NC group, the levels of PA, ALB, A / G, APOA1, APOA1 / B and IL-10 were decreased in MC group, and the levels of GLO, IL-1β, ANCA, VEGF and E IL-1β, ANCA, VEGF, E-selectin, PAF, GMP-140 and CD40L in MTX, TPT and XFC groups were significantly lower than those in MC group (P <0.05) , While the XFC group in the rise of PA, ALB, APOA1, APOA1 / B and other aspects was significantly better than other treatment groups. (P <0.05 or P <0.01). Compared with TPT and MTX group, the body weight of XFC group increased (P <0.05), and the arthritis index of XFC group was significantly lower than that before treatment , VEGF, E-selectin, PAF decreased, IL-10 was significantly increased (P <0.05).

Conclusion: Xinfeng Capsule can reduce the arthritis of adjuvant arthritis rats and improve the body weight and regulate pro- tein metabolism. The mechanism is that by down-regulating the expression of cytokines IL-1β, ANCA, VEGF, E-selectin, GMP-140, CD40L, Upregulates the expression of cytokines IL-10, inhibits inflammatory effects, enhances anti-inflammatory effects, inhibits vasculitis formation, improves microvascular circulation, regulates protein metabolism in vivo.