ARDAK AKHAYEVA1, IVAN SCOSAREV3, DANA GUPENOVA1, TATTIGUL KENGETAEVA1, DAN MORARU2, SORINA ANAMARIA PESTREA3, ANTONELLA CHESCA2,4, SEBASTIAN IONUT TOMA4
1Karaganda State Medical University, Kazakhstan, 4Faculty of Medicine, Transilvania University of Braşov, Romania - 2Clinical Hospital of Pneumophthisiology Brasov, Romania - 3Clinical Hospital of Psychiatry and Neurology Brasov, Romania
Objective: Conduct a comparative analysis of inflammatory biomarkers in the development of severity in community-acquired pneumonia
Material and method: In a prospective cohort study under the supervision of 110 children at the age of 5 to 14 years, of them 90 children with community-acquired pneumonia and 20 children from the control group, undergoing treatment in the respiratory department of Children’s Hospital of Karaganda, in which 43.64% were girls (95% CI 31.51% - 56, 33%) and boys 57.27% (95% CI 34.91% - 59.88%). The diagnosis of pneumonia was verified on the basis of standards ICD -10 (10th revision of the International Statistical Classification of Diseases) for diagnosis and treatment of pneumonia in children. General clinical examination was car- ried out in accordance with the protocols of examination of children with this pathology approved in the Republic of Kazakhstan, with the inclusion of: a bacteriological method of investigation, studies of TNF-α, IL-6 and PCT in serum by enzyme immunoassay.
Statistical processing of the obtained results of the difference in quantitative traits marker concentrations was carried out using a nonparametric Mann-Whitney’s U test
Conclusion: The results of our study indicate that as the severity of pneumonia increases, the titers of proinflammatory cytokines and procalcitonin in the blood serum of patients increase. The results of the study in patients with bacterial and viral pneumonia, proinflammatory cytokines (TNF-α, IL-6) and procalcitonin can be used as predictors to predict the severity of pneumonia.
Inflammatory biomarkers, community-acquired pneumonia, children, IL-6, TNF-α, PCT