THE EFFECTIVENESS OF THE ORAL VITAMIN B6 ON THE BEHAVIORAL SIDE EFFECTS OF PHENO- BARBITAL IN CHILDREN 2 TO 15 YEARS OLD WITH SEIZURES

FARZAD AHMADABADI¹, MANOUCHEHR BARAK², AFSHIN MASHAYEKHI3, MAHNAZ ZAREAKBARI^4*, NARJES JAFARI⁵, NAHID NAJAFI⁶

¹Pediatric Neurologist, Ardabil University of Medical Sciences, Ardabil, Iran - ²Pediatric Infectious disease specialist, Ardabil University of medical science, Ardabil, Iran - ³Neurologist, University of Istanbul, Istanbul, Turkey - ⁴Pediatrician, Ardabil University of Medical Science, Ardabil, Iran - ⁵Pediatric Neurologist, Shahid Beheshti University of Medical Science, Tehran, Iran - ⁶Pediatrician, Tehran University of Medical Science, Tehran, Iran

Objectives: Behavioral problems are considered as the side effects of phenobarbital consumption in children. Thus, the aim of this research is studying the effect of vitamin B6 on behavioral disorders due to use of phenobarbital in patients with seizure.

Patients and methods: In this study, 77 patients (Children with Seizures) were studied and divided to needs to be removed two groups. Phenobarbital along with vitamin B6, and phenobarbital along with a placebo were separately prescribed to the two groups for three months, and behavioral changes were recorded and the data were collected and provided for the statistical software.

Results: In the first three months, no significant difference was observed between the two groups, and in the second three months, the average value of hyperactivity behavior removed significantly decreased. In the drug group in the first three months and placebo group in the second three months, hyperactivity and aggressive behaviors significantly reduced moreover, With respect to all three behaviors, the placebo group in the first three months and drug group in the second three months the Were not significantly dif- ferent.

Conclusion: vitamin B6 can be effective in the reduction of hyperactivity behavior in the children.