EFFECTS OF CITRUS FRUITS ON BLOOD LIPID LEVELS: A SYSTEMATIC REVIEW AND META- ANALYSIS

GUANGNING KOU², ZIYAN ZHAO^1,2, XIN-YING DONG^1,2, YING ZHANG³, LI-YA GUO⁴, ZHI-QIN ZHOU^1,2

¹College of Horticulture and Landscape Architecture, Southwest University, Chongqing, China - ²Chongqing Southwest Institute of Fruits Nutrion, Chongqing, China - ³Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China - ⁴College of Sport Science and Education, Southwest University, Chongqing, China

Background: For management of hyperlipidemia and cardiovascular diseases, total fruit consumption that is increased is used. However, it is still not known if different subtypes like the citruses can play a role that is preventative. The response of the treatment and its magnitude is associated with the citrus in the improvement of the Total Cholesterol (TC), the Tri-glycerides (TG), the High Density Lipoprotein-Cholesterol (HDL-C), and the Low Density Lipoprotein-Cholesterol (LDL-C) which has not, until now been quantified systematically.

Method: The core objective of our analysis is t reviewing and conducting of the quantitative analyses of these studies which are evaluated for the effects of the ingestion of citrus into the blood lipid parameters. There are pertinent studies that are identified using a systematically proceeded PubMed search, and also the EMBASE of the China National Knowledge Infrastructure and the Cochrane Library until March 2017. The quality of study has been assessed by means of using a modified Jadad scale. These results were viewed on the basis of mean differences (WMD) with a confidence interval (CI) of 95% by making use of an unplanned impacts model.

Results: Randomized controlled testing with 7 in number having 282 participants had been included. According to the analysis a citrus fruit intake was significant in reducing TC (-5.18 mg/dL, 95% CI:-10.21 to -0.14, p=0.04) and LDL-C (-7.64 mg/dL, 95%CI:-12.27 to -3.01, p=0.001) in the participants, but the other lipid indexes were not significantly altered.

Conclusion: The results showed that in taking the citric fruitescan reduce the TC and the LDL-C and the effect and the size were moderate remaining ineffective on the HDL-C and the TG levels.