IS THERE ANY RELATIONSHIP BETWEEN MEAN PLATELET VOLUME, BONE MINERAL DENSITY AND VITAMIN D IN POSTMENOPAUSAL WOMEN?

MELTEM VURAL¹, MERAL MERT¹, BELGIN ERHAN², BERRIN GUNDUZ², BETUL YAVUZ KELES², ABDULLAH ESLEM ERDEM², AHMET BOZAN², HULYA ARSLAN³

¹Bakirkoy Dr. Sadi Konuk Training Hospital, Istanbul, Turkey - ²Istanbul Physical Medicine Rehabilitation Training Hospital, Istanbul, Turkey - ³Yozgat Public Hospital, Yozgat, Turkey

Introduction: Platelets have many functions notably atherogenesis, inflamation and atherothrombosis. Platelets precursors megakaryocytes are shown to contribute to bone formation with osteoblasts. It was indicated that vitamin D, which also played an important role in bone remodeling, had receptors in many tissues as well as receptors in platelets, and these receptors decreased in osteoporosis. In this study we aimed to evaluate the relationship between the mean platelet volume (MPV), which shows platelets and platelet functions, and bone mineral density (BMD) and serum 25-hydroxyvitamin D levels in postmenopausal women.

Material and methods: Three hundred sixty two postmenopausal women were included in this study. Their demographics, laboratory values and BMD were recorded. The subjects were divided into three groups as control, osteopenia and osteoporosis according to the results of BMD. MPV and platelet counts were investigated in these groups. Also correlation tests were performed to evaluate the relationship between platelet functions, vitamin D and BMD measurements.

Results: There was no difference in MPV and platelet counts between groups. No significant correlation was determined between MPV and serum 25-hydroxyvitamin D levels. However, based on the findings of our study, we established that there was a significant correlation between the platelet count and lumbar spine (L1-4) T score.

Conclusion: This study showed that there was no relationship between MPV and osteoporosis. MPV might be considered a less important indicator in serum 25-hydroxyvitamin D levels and osteoporosis.