TOTAL OXIDATIVE STRESS, TOTAL ANTIOXIDANT STATUS AND ERYTHROCYTES STATUS IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Objectives: In this prospective study, we attempted to determine the initial oxidative-antioxidative status using a new automated measurement method. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) levels and eryth- rocyte status in patients with acute ischemic stroke (AIS) were detect and compared to those in controls.

Methods: In total, 51 patients with AIS and 49 sex - and -age matched healthy participant as controls were enrolled the study. With the new automated extent practice developed by Erel, Serum TOS, TAS and OSI was measured. In addition serum erythrocytes level were measured.

Results: Subjects suffering AIS had higher TOS and OSI level than those control subjects. In contrast the TAS level were mode- rate higher in the controls than patients. In addition serum Mean corpuscular volume (MCV) and Red cell distribution width (RDW) levels were higher in patients with AIS in accordance with the controls.

Conclusions: Patients with AIS are subjected to oxidative stress and thus, erythrocyte indices have a significant impact on this type of patients. However, further studies are needed to confirm this relationship.