NO ASSOCIATION BETWEEN NAT1*15 AND BREAST CANCER, AND INTERACTION WITH RED MEAT

Introduction: Breast cancer is a complex disease characterized by the accumulation and combination of multiple genetic and environmental factors. Indeed, many studies have suggested that among powerful pre-carcinogens involved in breast carcinogenesis derived from aromatic and heterocyclic amines. These are either directly detoxified or converted into carcinogens by N-acetyltransfe- rases1 and 2. Both highly polymorphic isoenzymes are involved in the increased susceptibility to breast cancer. The objective of our work was to examine the effects of N-acetyltransferase 1*15 (NAT1*15) polymorphism and its relationship with red meat consumption and cigarettes smoking, on breast cancer risk.

Materiel and methods: The C and T alleles were identified by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism analysis for 60 Algerian patients with BC and 60 women controls.

Results: There was no association between NAT1*15 polymorphisms and Breast cancer. However, the red meat intake increased susceptibility to the disease (p=0.017, OR =5.537).

Conclusion: Our results suggest that NAT1*15 polymorphisms would not be involved in the pathogenesis of breast cancer. However, the red meat intake would be a risk factor for breast cancer in our population. This risk can be attributed to the high fat con- tained in the red meat.