CLINICAL CURATIVE EFFECT OBSERVATION AND NURSING EXPERIENCE OF TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE WITH ESOMEPRAZOLE COMBINED WITH ITOPRIDE

CHEN LIXIA, BAI BANJUN, SONG, XINLING, YOU YUN, HUANG MIN, YAN JIALI

Traditional Chinese Medicine Department, Guizhou Provincial People’s Hospital, 550002, China

Objective: To investigate efficacy and safety of treatment of gastroesophageal reflux disease with esomeprazole combined with itopride.

Method: 72 cases of gastroesophageal reflux disease patients that met the inclusion criteria were randomly divided into two groups, with 40 cases in treatment group and 32 cases in control group. There was no significant difference in age and sex of the two groups (P> 0.05). The treatment group was treated with esomeprazole + itopride, while the control group was treated with esomeprazole + domperidone. Course of treatment ran 4 weeks. The clinical efficacy and safety were observed.

Result: Clinical remission rate and recurrence rate of treatment of gastroesophageal reflux disease with esomeprazole combined with itopride are superior to the control group, and itopride brought no significant adverse reactions.

Conclusion: Esomeprazole combined with itopride is an ideal drug for treatment of gastroesophageal reflux disease, safe and reliable and with less adverse reactions.