ANTI-INFLAMMATORY EVALUATION OF LIPOSOMAL PREDNISOLONE IN WISTAR RATS

SEYED HOJJAT HOSSEINI*¹, HAMID REZA ESHRAGHI¹, MEHRDAD HAMIDI²

¹ Department of Veterinary basic science, Science and Research branch, Islamic Azad University, Tehran, Iran - ² Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, Iran

The aim of the present study was to evaluate the anti-inflammatory ability of liposomal prednisolone in a carrageenan induced acute inflammatory paw edema model. Drug delivery to inflammatory tissue via liposomal nanoparticles may improve therapeutic agents’ risk-benefit ratios. prednisolone encapsulated in long-circulating liposomes can inhibit inflammation after administration. The mechanism by which liposomal prednisolone inhibits Production of inflammatory factor. Variable efficacies have been reported for prednisolone drugs as anti-inflammatory treatment. Liposomal prednisolone was administered to male Wistar rats. carrageenan at a concentration of 1% was injected into hind paw of rats. The thickness of paws was measured by caliper within 0, 1, 2, 3, and 4 hours after the injections to confirm the inflammation. Blood samples were collected immediately after carrageenan injection and also 12 h thereafter. The sera were separated for measurements of interleukin 6 (IL-6). The prednisolone and liposomal prednisolone are efficacious in controlling the paw sizes, as indicators of inflammation; the liposomal prednisolone is remarkably more effective in controlling the inflammation in long term. Both the drug forms were clearly efficient in lowering the IL-6 level. Mostly noteworthy, the liposomal prednisolone was remarkably more efficient in lowering IL-6 levels.