RELATIONSHIP BETWEEN METABOLIC SYNDROME AND METABOLIC SYNDROME SCORE AND INSULIN RESISTANCE AND BETA CELL FUNCTION IN KOREAN ADULTS WITH TYPE 2 DIABETES MELLITUS

HYUN YOON*, SUNG GIL KIM**, GWANG SEOK KIM***, BU YEON PARK****

*Department of Biomedical Laboratory Science, Hanlyo University, 94-13, Hallyeodae-gil, Gwangyang-eup, Gwangyang-si, Jellanamdo, South Korea - **Department of Radiological Science, Hanlyo University, 94-13, Hallyeodae-gil, Gwangyang-eup, Gwangyang-si, Jellanam-do, South Korea - ***Emergency Medical Technology, Chungbuk Health and Science University, 10, Deogam-gil, Naesu-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do South Korea - ****Department of Hospital Administration, Seonam University, 439, Chunhyang-ro, Namwon-si, Jeollabuk-do, South Korea

Introduction: The present study was conducted to assess the relationship between metabolic syndrome (MetS) and metabolic syndrome score (MSS) and insulin resistance and beta cell function in Korean adults with type 2 diabetes mellitus (T2DM).

Material and method: This study included 541 adults with T2DM using 2010 Korean National Health and Nutrition Examination Survey (KNHANES) data.

Results: The key study results were as follows: First, after adjusted for the related variables [age, gender, smoking, drinking, exercising, TC, 25(OH)D, and BMI], metabolic syndrome (p = 0.967) and MSS increases (p = 0.131) were not significantly associated with the HOMA-IR levels. Second, after adjusting the related variables (except BMI), MetS (p = 0.264) and MSS increases (p = 0.359) were not significantly associated with HOMA-B levels. However, when further adjusted for BMI, MetS (p = 0.004) and MSS increases (p = 0.010) were inversely associated with HOMA-B levels.

Conclusion: Metabolic syndrome and increase of metabolic syndrome score were inversely associated with beta cell function, but were not independently associated with insulin resistance in Korean adults with T2DM.