NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO IN CARDIAC AND NON-CARDIAC ARREST DISTINCTION: A RETROSPECTIVE COHORT STUDY

CEREN SEN TANRIKULU*, NAZIRE BELGIN AKILLI*, YAHYA KEMAL GÜUNAYDINI*, ÖZNUR KÖYLÜ**

*Department of Emergency Medicine, Konya Training and Education Hospital, Konya, Turkey - **Department of Biochemistry, Konya Training and Education Hospital, Konya, Turkey

Introduction: Cardiopulmonary arrest (CPA) is a major cause of death in developed countries. While 80% of the arrests occur due to cardiac pathologies, 20% occur due to non-cardiac pathologies. Determining the underlying pathology is very important. In this retrospective study, we examined the potential utilities of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cardiac and non-cardiac arrest distinction.

Materials and methods: We enrolled the following participants: 136 patients with cardiac arrests and 152 patients with noncardiac arrests between January 2012 and December 2015. The distinction was made primarily on whether cardiac pathology was present. The cardiac pathology was determined by using cardiac enzyme levels, electrocardiographic and echocardiographic findings, angiographic results, and patient history.

Results: Cardiac arrests were observed more frequently in male patients, while the number of non-cardiac arrests was greater in female patients (p=0.018). PLR and NLR were higher in non-cardiac arrests than in cardiac arrests (p<0.001 for PLR and p=0.001 for NLR). None of these parameters showed any effect on the 30-day mortality. The sensitivities, specificities, positive predictive values (PPV), and negative predictive values (NPV) of the PLRs and NLRs were 80.1%, 42.2%, 64.0%, and 62.3% and 49.7%, 73.5%, 68.8%, and 55.4%, respectively. The area under the curve (AUC) for the PLR was 61.7%, and the AUC for the NLR was 61.0%.

Conclusion: We suggest that the NLR and PLR can be helpful in the differentia