Authors
ASUDE AKSOY1*, SERDAR DURAK2
, TURKAN OZTURK3
, NILUFER AVCI4
, YALCIN CIRAK5
, AYSE NUR DEGER6
, YILMAZ BILGIC7
,
SULEYMAN SERDAR KOCA2
, METE OZCAN8
, SEVIL GOKTAS9
, AHMET BOZDAG10
Departments
1
*Firat University, Medical Faculty, Medical Oncology - 2
Firat University, Medical Faculty Internal Medicine - 3
Medical Oncology,
Medical Faculty, Karadeniz Teknik University - 4
Bursa Ali Osman Sonmez Oncology Hospital, Medical Oncology - 5
Istanbul
Bahcesehir University, Medical Faculty, Medical Oncology - 6
Dumlupınar University, Medical Faculty, Pathology - 7
Inonu
University, Medical Faculty, Gastroenterology - 8
Firat University, Medical Faculty, Biophysic - 9
Denizli State Hospital, Medical
Oncology - 10Elazig Education and Research Hospital, General Surgery, Turkey
Abstract
Introduction: The potential effects of serum albumin and albumin-globulin rate on survival were investigated in patients with
gastric carcinoma.
Materials and methods: The biochemical values of 204 patients under chemotherapy evaluation were obtained retrospectively
from archive data. Albumin-globulin ratio values were calculated using albumin/total protein-albumin formula. The values of albumin-globulin
ratio and albumin were categorized as 3 groups using receiver operating characteristic analysis and a descending
order.
Results: The calculated cut-off value for albumin-globulin ratio was 1.14: 34.4-79.7 by receiver operating characteristic. The
median survival was 20.7 months (15.9-25.5), 20.1 months (15.1-25.1), 16 months (11.8-20.1 ), respectively in 1st, 2nd, 3rt groups for
albumin-globulin ratio (p=0.46). The median overall survival was 18.3 months (12.3-24.2), 21.6 months (16.8-26.3), 18.01 months
(13.5-22.4) in 1st , 2nd, 3rt groups for albumin, respectively (p=0.52). There were no statistical significant differences by KaplanMeier
method for albumin-globulin ratio, albumin p>0.05. The effects of clinicopathological and biochemical characteristics on
mortality were assessed by Cox-proportional hazard regression analysis. The independent predictors of mortality were observed high
grade, the presence of perineural invasion of the tumor, high nodal involvement (p:0.01, p:0.001, p:0.01), respectively.
Conclusion: Albumin-globulin ratio and albumin values alone may not be useful parameters to predict mortality and survival
in patients with gastric carcinoma
Keywords
Albumin-globulin ratio, albumin, gastric carcinoma, predictive, survival
DOI:
10.19193/0393-6384_2016_3_78