Authors

HAKAN AKDAM1 , ALPER ALP2 , ÖZGÜL ÖZBEK3 , AYŞEGÜL KAHRAMAN3 , MELIH ÖZIŞIK1 , HAYRI ÜSTÜN ARDA4 , YAVUZ YENIÇERIOĞLU1

Departments

1 Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Aydin, Turkey - 2 İzmir Tepecik Training and Research Hospital, Nephrology Clinic, İzmir, Turkey - 3 Adnan Menderes University Adnan Menderes University Practice and Research Hospital, Peritoneal Dialysis Unit, Aydin, Turkey - 4 Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey

Abstract

Introduction: Malnutrition is quite common in peritoneal dialysis patients and is associated with high mortality. Bioimpedance indices and phase angle are used frequently in nutritional studies. Phase angle measured by bioimpedance analysis indicates body cell mass and soft tissue mass and changes in the quality and quantity of the mass; therefore, it is used as a nutritional marker. We aimed to evaluate nutritional status of peritoneal dialysis patients by bioimpedance analysis.

Materials and methods
: 38 peritoneal dialysis patients and 37 healthy individuals were studied. All individuals’ bioimpedance indices, phase angle measurements (800 μA current, 50 kHz frequency) were carried out by using multifrequency bioimpedance device. Nutritional biochemical markers were measured.

Results
: Peritoneal and control group phase angle were detected 4.48±0.86 and 5.97±0.85, respectively (p<0.001). Albumin, total protein, transferrin, potassium, calcium, hemoglobin, HDL-cholesterol levels were significantly lower in peritoneal group. The mean normalized protein catabolic rate (nPCR) was found to be 1.41±0.44 g/kg/day, in peritoneal dialysis patients. There was a significant positive correlation between phase angle and nPCR (p=0.001, r=0.516). Phase angle was positively correlated with albumin, total protein, transferrin, potassium, hemoglobin, body cell mass/weight (%), lean tissue mass/weight (%), lean tissue index, body cell mass/weight (%), and negatively correlated with age, creatinine, phosphorus, parathyroid hormone, alkaline phosphatase, C-reactive protein, fat tissue mass/weight (%), fat tissue index. Independent predictors of phase angle were albumin, age and lean tissue index revealed in regression analysis.

Conclusion
: Phase angle was significantly lower in peritoneal dialysis patients. Bioimpedance parameters, especially phase angle reflect the nutritional status in peritoneal dialysis patients.

Keywords

Bioimpedance, lean tissue index, nutrition, phase angle, peritoneal dialysis

DOI:

10.19193/0393-6384_2016_3_75