1*, XIAOYUAN SUN1*, HAIYING GUO1
, XIAOQING WU2
, WUPING BAO1
, YUQING CHEN1
, ENHAI CUI2
, QIANG LI
, XIN ZHOU1
Department of Respiratory Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080,China
Department of Respiratory Medicine, Hu Zhou Central Hospital, Huzhou 313000, China
Introduction: We reviewed and analyzed the clinical manifestations, radiographic features, laboratory results, treatments, and
outcomes for patients with cryptogenic organizing pneumonia (COP).
Materials and methods: Thirty cases of COP confirmed by pathology between November, 2007 and May, 2014 from two comprehensive
hospitals in Shanghai and Huzhou were retrospectively reviewed. The clinical manifestations, radiographic features,
laboratory results, treatments, and outcomes were collected and analyzed.
Results: The mean age of COP patients was 55.2±15.2 years, and their main symptoms included cough, phlegm and fever.
Patchy consolidation was the most common lesion, followed by mass/nodule. The leukocyte count was normal while the neutrophil
percentage was increased in most patients. Platelet count, C-reactive protein, and erythrocyte sedimentation rate were increased.
Pulmonary function test results could be normal, restrictive, obstructive, or mixed pattern. The diagnosis of COP was mainly confirmed
through computerized tomography (CT)-guided percutaneous needle lung biopsy. COP patients responded poorly to antibiotics
but responded well to corticosteroid therapy.
Conclusion: The clinical manifestations, radiological changes, and laboratory results from COP are nonspecific. CT guided
percutaneous needle lung biopsy is the key for the diagnosis. Strengthening the recognition of COP would avoid the use of antibiotics.
cryptogenic organizing pneumonia, clinical manifestations, radiographic features, lung biopsy