, BÜNYAMIN SARITAŞA
, İSMAIL AYDINB
, TAYYAR ŞAŞMAZC
,"EBRU SERINSÖZ LINKED
Mersin University School of Medicine, Department of Gastroenterology, Mersin , Turkey - b
Mersin Association of Family
Practitioner, Akbelen 70. Yil Family Health Center, Mersin, Turkey - c
Mersin University School of Medicine, Department of Public
Health, Mersin, Turkey - d
Mersin University School of Medicine, Department of Pathology, Mersin, Turkey
Introduction: Celiac disease affects 0.6 to 1.0% of the population worldwide. Undiagnosed CD has been significantly linked
with a nearly 4-fold increase in all-cause mortality. The present study was designed to investigate the prevalence of undiagnosed
Celiac Disease (CD) and to study the characteristics of these patients in the adult population in Mersin, Turkey.
Materials and methods: This study was undertaken through the time frame of June 2011- January 2013. Adults aged 18 and
older living in Mersin are included in the study. Family physicians and volunteers registered to these family physicians were selected
district-wide through random sampling method, stratified sampling method, respectively. Participants were tested for anti-tissue
transglutaminase (anti-tTG) and anti-Deaminated Gliadin Peptide(DGP) IgA and IgG Enzyme-Linked ImmunoSorbent Assay
(ELISA). Small intestinal biopsies were obtained from the seropositive patients, and they were examined according to the Marsh classification.
Results: 1.554 people participated in the study. Mean age was 42 years and 50,4% were female. 12 (0.77%) of the participants
showed anti-tTG/DGP IgA or IgG positivity. The mean age of seropositive participants was 41 years and 83% of them were female.
All seropositive participants were either human leukocyte antigen (HLA)-DQ2 or DQ8 positive.
Conclusion: This study is the first population-based prevalence study of CD in Turkish adult population. We found that seroprevalence
of CD as 0.77% and biopsy proven CD prevalence as 0.39%. Patients with iron deficiency anemia or with relatives diagnosed
as CD must be evaluated closely.
Celiac Disease, Prevalence, Population, Mersin, Turkey