Authors
KAZIM ÇAĞLAR ÖZÇELIK1
, HALUK ULUCANLAR2
, SEVIM TURANLI2
, İSMAIL ZIHNI1
, OKTAY KARAKÖSE1
, HÜSEYIN PÜLAT1
,
ALPASLAN FEDAI ÇALTA3
, HÜSEYIN EKEN4
Departments
1
Suleyman Demirel University Medical Faculty, Department of Surgical Oncology, Isparta - 2
Ankara Oncology Education and
Research Hospital, Department of General Surgery, Ankara - 3 Bandırma State Hospital, Department of General Surgery, Balikesir - 4
Mengücek Gazi Education and Research Hospital, Department of General Surgery, Erzincan, Turkey
Abstract
Aim: This study is conducted to identfy clinical significance of multicentricity and its effects on thyroid papillary carcinoma.
Materials and methods: Hospital records of 250 patients who were operated and diagnosed as thyroid papillary carcinoma
according to pathology report between 2000-2007 in Ankara Oncology Hospital were analyzed retrospectively.
Results: Among the 250 paitents who were diagnosed with thyroid papillary carcinoma and followed 102.5 mounts in average,
multicentricity was identified in the 43.2% of the patients. Multicentricity was detected in 57.1% (32 patients) of the 56 patients who
had follicular variant of thyroid papillary carcinoma which was detected in their pathology report. In comparison with other subgroups,
multicentricity was seen in a higher statistical rate in follicular variant. However, a statistically significant relation between them
could not be founded (p:0.06). Among the 13 multicentric patients, vascular invasion was seen in 10 patients (76.9%) and there was a
statistical correlation (p<0.05). Although multicentricity was seen in 46.8% (36 patients) of the 78 patients with lymph node metastasis
at the time of diagnosis, there was not a statistical correlation. 34 patients had recurrence and multicentricity was seen in 19 of them
(55.9%) with no statistical relation. Moreover, no correlation of multicentricty with general survival and disease-free survival was
found.
Discussion: Multicentricity characterized with high recurrence rate and lymph node metastasis should be accepted as a bad
prognostic factor and in this situation aggressive treatment protocol should be used.
Keywords
Multicenticity, papillary carcinomas, thyroid
DOI:
10.19193/0393-6384_2016_1_32