Authors
GIUSEPPA LA CAMERA, GIOVANNI CANTARELLA, PAMELA REINA, VALERIA LA ROSA, MIRKO MINERI, VALERIA CARNEMOLLA,
DANILO CARMELO GRASSO, PIERFILIPPO DI MARCO
Departments
Department of Medicine and Surgery, University of Catania, Italy
Abstract
Introduction: Cardio-renal syndrome (CRS) is a combined disorder in which acute or chronic dysfunction of one of the
organs causes acute or chronic dysfunction in the other. CRS affects 20-40% of patients in intensive care.
Materials and methods: The study enrolled 27 patients hospitalized in the ICU of Catania’s Gaspare Rodolico Polyclinic
Hospital between April 2014 and May 2015. The patients were 18 to 85 years old, 15 females and 12 males, who were admitted to
ICU with worsening of a chronic cardiovascular pathology, potentially classifiable as Type 1 or 2 CRS.
Results: The study found that neutrophil gelatinase-associated lipocalin (NGAL) was able to predict acute renal damage and
provided a risk stratification, and when B-type natriuretic peptide (BNP) was also used they increased the capacity to predict a clinical
exacerbation.
Conclusion: The findings confirmed that NGAL and BNP values are helpful biomarkers in the diagnosis and treatment of
CRS.
Keywords
Cardio-renal syndrome, cardiac insufficiency, renal insufficiency, biochemical markers, intraglomerular perfusion
DOI:
10.19193/0393-6384_2016_1_07
