PING QI1, HAO CHEN2, SHUN-YU LU3, ZHI-GUO YIN1, JUN LIN
1Department of pharmacy, Ankang municipality center hospital, Ankang, Shanxi, P.R.China, 725000 - 2Department of endocrinology, Ankang municipality center hospital, Ankang, Shanxi, P.R. China. 725000 - 3Department of pharmacology, Guangxi Medical University, Nanning, Guangxi, P.R.China, 530021 -
The synthesis, characterization and pharmacological activities of a new series of 4-Hydroxy-2(3H)-benzoxazolone are described.CCl4-induced acute liver injury model in mice was determined by serum alanine aminot ransferase(ALT). Among the synthesized compounds, compound 4-hydroxy-2(3H)-benzoxazolone, 4-Acetyl-2(3H)-benzoxazolone, 3-4-Acetoxy-2(3H)-benzoxa- zolone was found to be the most promising compound for antihepatis.
4-Hydroxy-2(3H)-Benzoxazolone, Liver injury Carbon tetrachloride