Authors

FATMA AVCI MERDİN1, ALPARSLAN MERDİN2

Departments

1Internal Medicine Clinic, University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey - 2Hematology Clinic and Bone Marrow Transplantation Unit, University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey

Abstract

Introduction: Iron deficiency anemia (IDA) is commonly seen among premenopausal women with anemia. Iron is a vital nutrient that plays a role in some metabolic pathways. This study aims to determine whether there is a relationship between iron deficiency anemia and lipid profile by comparing serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol levels in patients with IDA and healthy controls.

Materials and methods: The study included 56 female patients admitted to the Internal Medicine Outpatient Unit of University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital between 15 October 2016 and 30 June 2017. All 56 patients were diagnosed with iron deficiency anemia. Patients with certain diseases that may affect lipid profile such as hypertension, diabetes mellitus, and thyroid diseases, as well as those using medications that could affect serum cholesterol levels were not included in the study. Besides, patients with known infectious or inflammatory diseases were excluded from the study. The study also included 37 healthy women as control group. All of 37 healthy women were admitted to outpatient unit for routine tests and they had no known illnesses, either anemia or any known clinical condition that could affect their lipid levels. All of 37 healthy women and all of 56 female patients were 18-45 years old. Serum triglyceride, total choles- terol, HDL cholesterol, LDL cholesterol, iron, and ferritin levels, and hemogram parameters were evaluated retrospectively on the electronic patient file system.

Results: The triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol levels were compared between the two groups, and there were no statistically significant differences between the two groups in terms of triglyceride and HDL cholesterol levels (p>0.05). However, there was a statistically significant difference between the two groups with regard to total cholesterol levels (Z= -2.245; p=0.025). There was a statistically significant difference between the two groups with respect to LDL choles- terol levels (Z= -1.998; p=0.046). LDL cholesterol levels of patients with iron-deficiency anemia were found to be significantly higher than those of the control group. The mean age of the patients with iron deficiency anemia was also found to be significantly higher than that of the control group (Z= -2.925, p=0.003).

Conclusion: It should be kept in mind that LDL cholesterol levels might be affected in patients with iron deficiency anemia.

Keywords

Iron deficiency, anemia, lipid profile, relation.

DOI:

10.19193/0393-6384_2018_6_303