JING LI#, AILI WANG#, LU SONG, JIGUANG ZHAO*
Department of Clinical Laboratory, Number 6 People’s Hospital of Qingdao, China
Purpose: To investigate the expressions of astrocytic upregulation gene-1 (AEG-1), cadherin (E-ca) and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with esophageal cancer, and their clinical significance in diagnosis, treatment, and prediction of prognosis.
Methods: A total of 160 patients were used for this study, and they were divided into two groups: esophageal carcinoma group and para-cancerous (control) group. There were 80 patients in the esophageal carcinoma group which comprised 58 males and 22 females within the age range 28 - 70 years (mean age = 49.26 ± 15.32 years). The para-cancerous group consisted of 80 patients with adjacent tumor-free tissue samples within the same period. They were confirmed by clinical pathology. Specimens from the patients were subjected to immunohistochemistry and Western blotting.
Results: The positive expressions of AEG-1 and IGFBP-3 in patients with esophageal carcinoma were significantly higher (p < 0.05) than those of corresponding para-cancerous tissue. The positive expression of E-ca was significantly lower (p < 0.05) than that of the corresponding para-cancerous tissue. The positive expressions of the three genes were not correlated with sex, age, site of tumor and tumor pathology type, but were related to the degree of tumor differentiation, depth of invasion, clinical stage and lymph node metastasis.
Conclusion: The expressions of AEG-1, E-ca and IGFBP-3 in patients with esophageal cancer can provide important reference values for the early diagnosis and treatment of the disease, and improve its prognosis.
Esophageal carcinoma, AEG-1, E-ca, IGFBP-3, Treatment.