BAIMING LOUXIN, FANGXIAOYAN. MIAOYANYAN, MIAOMINGSAN
Henan University of Traditional Chinese Medicine zhengzhou 450046, China
Objective: To observe the effect of arctiin on rat hyperuricemia model, and to explore the intervention effect and mechanism of arctiin on hyperuricemic nephropathy.
Methods: Adopt the method of adenine and ethambutol joint application to establish the rat model of hyperuricemia.
Conclusion: Arctiin can significantly reduce serum uric acid(UA), creatine (Cr), Urea nitrog en (BUN), Tumor necrosis factor-α(TNF-α), Mononuclear chemotactic protein -1 (MCP-1) level, xanthine oxidase (XOD) activity, the level of cyclooxyge- nase -2 (COX-2) in the renal tissue homogenate,and it can significantly reduce the degree of pathological injury of the thymus, spleen and kidney tissue. Results: Arctiin is effective for the treatment of hyperuricemia.
Hyperuricemic nephropathy, Animal model,Adenine, Ethambutol.