FUBAO JIA1, GUANJUN SUN1, FENGJUN CAO1, XIUYUN SHI2, HONGLIANG GE1
1Department of internal neurology, Shanxian Central Hospital, Shanxian, 274300, China - 2Department of Test, Shanxian Central Hospital, Shanxian, 274300, China
The purpose of this article is to explore the risk factors associated with non-thrombolytic hemorrhagic transformation in patients with acute ischemic stroke. It also provides a clinical prevention and treatment method for hemorrhagic transformation, which provides a theoretical basis for the risk assessment of patients in the future. A retrospective analysis method was used to analyze 60 patients who failed to respond to thrombolysis or were not willing to accept thrombolytic therapy in our emergency department of Neurology in January 2016 - January 2017. Hemorrhagic transformation was used as a sign, which was divided into hemorrhagic transformation group and non-hemorrhagic transformation group. There were 30 patients in each group. The basic information, clinical indicators and imaging data of patients' medical records were collected. After that, SPSS 20 software was used for statistical analysis. Logistic regression analysis showed that the factors of the difference were statistically significant for a total of 5. They are the infarction area (OR=3.48, CI: 1.41-8.86, P=0.006); NIHSS score (OR=1.068, CI: 1.014-1.128, P=0.009), high blood lipids (OR=2.78, CI: 1.36-5.62, P=0.009), diabetes mellitus (OR=1.062, CI: 0.967-1.284, P=0.006), urine protein (OR=2.12, CI: 1.68-3.06, P=0.000). It can be concluded that NIHSS score, infarct area, hyperlipidemia, diabetes, and urine protein are independent factors of hemorrhagic transformation.
ischemic stroke, non thrombolytic therapy, hemorrhagic transformation