Department of Respiratory, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, China


Introduction: The objective of this study was to investigate influential factors of medication adherence of inhalation devices in patients with chronic obstructive pulmonary disease (COPD)through the following criteria: application scores of the inhalation devices, physician effective guidance, the number of acute exacerbation, adverse drug reactions (ADRs).

Materials and methods: A total of 130 patients with COPD who sought medical care in the hospital were recruited for the study. Questionnaire survey was performed to evaluate medication adherence of inhalation devices. The obtained data were analyzed by using a t-test, a Chi-square test, and a binary logistic regression analysis to determine the relationship of the above various factors with medication adherence. Then, the 130 patients were randomly divided into an intervention group and a control group. The intervention group was interviewed by the physician in the process of using inhalation devices. After 3 months and 6 months, observed the difference of the two groups.

Results: The analysis indicated that there was a close relationship between medication adherence of inhalation devices and the following criteria: application score of the inhalation devices, ADRs, the number of acute exacerbations, and effective guid- ance of physicians. Compared with the control group, application scores of the inhalation device of the intervention group were significantly improved. The number of acute exacerbation decreased by 16%, the incidence of ADRs in the intervention group was 13.6% lower than that in the control group, and the difference was statistically significant.

Conclusion: After physician effective guidance, the application scores of the inhalation devices were improved, the number of acute exacerbation and ADRs decreased. Physician should take intervention measures in accordance with the influential factors of medication adherence of inhalation devices to improve treatment efficacy of COPD


chronic obstructive pulmonary disease (COPD), inhalation device, medication adherence, influential factor