YANG LI1, XIU-QIN WU2, QI FAN3, FU-SHUN WANG3, JIAN-ZHONG LI3, QING YANG
1Psychological center, school of management, Nanjing forest police college,P.R.China, 210023 - 2Nanjing University of Chinese Medicine Hanlin College, P.R.China, 225300 - 3School of Psychology, Nanjing University of Chinese Medicine, P.R.China, 210023
Objective: To investigate the variations in levels of visinin-like protein-1 (VILIP-1) and high sensitive C-reaction protein (hs-CRP) in cognitive dysfunction after stroke and the clinical significance.
Methods: A total of 110 patients with ischemic stroke (Stroke group) were divided into two groups according to the MoCA scale at 3 months after attack, i.e. the cognitive dysfunction (n=53) and normal cognition group (n=57); at the same time, 50 sub- jects who attended the physical examination were enrolled in the control group. General data of patients were collected from patients, including gender, age, education years, disease history and biochemical indexes, and enzyme-linked immunosorbent assay was carried out to detect the levels of VILIP-1 in and immuno-scatter turbidmetry to detect the levels of hs-CRP in serum of all groups.
Results: In 110 stroke patients, there were 53 with cognitive dysfunction (48.18%). In the stroke group, the level of VILIP-1 was higher than that in the control group [(449.20±100.77) ng·L-1vs. (332.78±92.13) ng·L-1; t=6.95, p<0.001]. In the cognitive dysfunction group, the level of VILIP-1 was higher than that in the normal cognition group [(530.72±72.05) ng·L-1vs. (373.41±50.00) ng·L-1; t=12.965, p<0.001]. Significant increases were identified in HIHSS score and hs-CRP in the cognitive dysfunction group in comparison with the levels of normal cognition group, and the difference had statistical significance (p<0.01), suggesting that the level of hs-CRP goes up against the severity in cognitive dysfunction with aggravation in nerve func- tions.
Conclusion: After stroke, VILIP-1 is increased in patients with cognitive dysfunction, suggesting that it can serve as a pre- dictor for cognitive dysfunction after stroke; hypertension and the level of VILIP-1 in serum are independent risk factors of cogni- tive dysfunction after stroke, indicative of the importance of antihypertensive therapy. In light of the close correlation between hs- CRP and cognitive dysfunction after stroke, it can be used to evaluate the severity of cognitive dysfunction of patients.
Stroke, cognitive dysfunction, VILIP-1; hs-CRP.