CHUN-FENG TIAN, BAI-YU SU, YU-HONG TONG, XU-HONG ZHAO, YAN WANG, SHUN-BAO LI, BU-LANG GAO
Shijiazhuang First Hospital (Chun-Feng Tian, Bai-Yu Su, Yu-Hong Tong, Xu-Hong Zhao, Bu-Lang Gao), Baoding New District Hospital (Yan Wang), and Baoding First Central Hospital (Shun-Bao Li)
Purpose: To investigate the effects of statins on renal function in atherosclerotic patients.
Materials and methods: Two-hundred-forty patients with carotid atherosclerotic plaques were enrolled and randomly divided into four groups. Group A had atorvastatin 10 mg/d, group B had simvastatin 20 mg/d, group C had rosuvastatin 5 mg/d and group D had lovastatin 20 mg/d before sleep once daily for four months. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), Cystatin C (Cys C), high sensitive C reactive protein (hsCRP), blood urea nitrogen (BUN) and serum creatinine (SCr) were tested before med- ication, 4 and 15 weeks of follow-up.
Results: No significant (P>0.05) differences existed in the demographic data among the four groups. Significant (P<0.05) decreases in TG, TC, LDL, hsCRP and Cys C but significant (P<0.05) increases were found in HDL at weeks 4 and 15 compared with before medication (Table 2-3). No significant (P>0.05) differences existed in the ALT, AST and BUN at different time points. The SCr was significantly (P<0.05) decreased at week 15 compared with before medication. No significant (P>0.05) decrease was in the BUN after medication, but significant (P<0.05) decrease in the SCr at week 15 and in the Cys C, hsCRP, TC and LDL at weeks 4 and 15 (Table 4-5). However, no significant (P>0.05) difference existed in these parameters in the four groups.
Conclusion: Statins have a potential protective effect on renal function besides reducing serum lipids and inflammatory factors.
Carotid atherosclerotic plague, Stains, Renal Function, Cystatin C, C reactive protein