1Zhejiang Kaihua Clinical Laboratory Center - 2Zhejiang Provincial People’s Hospital - 3Department of Pediatrics, Affiliated Hospital of Changchun University of Traditional Chinese Medicine


Objective: To study correlations between changes in serum TNF-α, IL-6 and CRP in craniocerebral injury patients, and sever- ity of craniocerebral injury.

Methods: A total of 120 craniocerebral injury patients were classified as slight, moderate, and severe, according to degree of craniocerebral injury, with 46, 38 and 36 cases, respectively. The control group comprised 35 healthy volunteers who were physically examined in our hospital. Serum levels of TNF-α, IL-6 and CRP as a function of time (1 day, 3 days, and 7 days) after craniocerebral injury, were monitored with ELISA kits.

Results: Serum levels of TNF-α, IL-6 and CRP in the slight, moderate and severe craniocerebral injury patients at the three time intervals after injury were significantly higher than corresponding values in the control group (p < 0.05). Serum TNF-α, IL-6 and CRP levels in severe injury group were significantly higher than their levels in the slight and moderate groups on days 1, 3 and 7 after injury, and their levels in the slight craniocerebral injury group were lower than in the medium group at the same time points (p < 0.05). Serum levels of TNF-α, IL-6 and CRP levels at the three time points after injury had positive correlations with degree of injury

Conclusion: These results indicate that craniocerebral injury patients have elevated serum TNF-α, IL-6 and CRP levels, which levels vary in direct proportion to the severity of injury.


Dynamic Changes, TNF-Α, IL-6, CRP Of Serum, Craniocerebral injury