XING-PENG XIAO, XUAN HE, YI-FAN JIA, HAN-LIN REN, YAN-SHU XU
Department of anaesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
Objective:To explore the effects of sufentanil and fentanyl on hemodynamics and stress responses in induction of general anes- thesia in elder patients.
Methods: Randomly, we selected a total of 100 elder patients who would undergo general anesthesia in this hospital, and those patients were divided into two groups, i.e. the sufentanil group (n=50) and the fentanyl group (n=50). Respectively, induction in the sufentanil group and the fentanyl group was carried out with sufentanil (0.5 μg/kg) and fentanyl (4.0 μg/kg). Items to be observed in this study included the changes in hemodynamics and respiratory functions before induction and 1 min, 5 min and 10 min after intubation, and the variations in blood glucose and norepinephrine in venous blood that was drawn at 1 min after intubation.
Results: From 1 min after intubation, the indicators of hemodynamics of patients in the sufentanil group were significantly lower than those in the fentanyl group and the difference had statistical significance (p<0.05), but at 10 min after intubation, no sta- tistically significant difference was identified between two groups (p>0.05); at 1 min and 5 min after administration of drugs, respi- ratory depression in varying degrees was observed, while the reduction in respiratory rate in fentanyl group was more obvious than that in the sufentanil group, and the difference had statistical significance (p<0.05). However, comparison of the partial pressure of carbon dioxide (PaCO2) after intubation between two groups showed no statistically significant difference (p>0.05). At 1 min after intubation, decreases were identified in blood glucose and norepinephrine in the sufentanil group, while in the fentanyl group, these two indicators were elevated, and the differences between two groups had statistical significance (p<0.05).
Conclusion: Sufentanil, with less inhibitory effect on respiration, can stabilize the hemodynamics, maintain the stability of cir- culation system and inhibit the stress response in the induction of general anesthesia for elderly patients. Thus, sufentanil is more applicable to the induction of general anesthesia.
Sufentanil, fentanyl, hemodynamics, stress response