FATMA AYKAŞ1, DENIZ AVCI2, FERHAT ARIK2, ALI ÇETINKAYA2, OYKUN KOLAĞASI1, MUSTAFA OZEN2, ARZU OGUZ2, AYDIN UNAL3, EMINE USLU2, BADE ERTURK ARIK4
1Antalya Training and Research Hospital, Department of Hematology - 2Kayseri Training and Research Hospital, Department of Internal Medicine - 3University of Erciyes, Department of Nephrology - 4University of Erciyes, Department of Family Practice
Objective: Effects of concomitance of genetic factors with diabetes mellitus have been researched for a long time. We investi- gated relationship between insulin resistance and ABO/Rh blood group systems, which has not been investigated before.
Material and method: In the present study, medical files of patients who applied to outpatient clinics of Endocrinology and Metabolism, Internal Medicine and Diabetes at Kayseri Training and Research Hospital between dates September 2010 and March 2015, and who had been studied for, but not diagnosed with diabetes mellitus, were retrospectively evaluated. Among patients, those with HOMA-IR≥ 2.5 were accepted as having insulin resistance, and enrolled in the study. Patient whose blood groups were recorded in the hospital records or blood groups were determined later during control visits. The control group composed of healthy indivi- duals who applied to the same hospital.
Results: When compared with the control group, blood type A was significantly higher in patients with insulin resistance (p=0.022). The adjusted p value was 0.264 when Bonferroni correction was used. Blood type O group was also determined less significantly higher in patients with insulin resistance (p=0.055). The adjusted p value was 0.060. No significant difference was determined in blood types B and AB (p=0.49 and 0.12, respectively). Blood type A Rh (+) was 45.2% in patients with IR whereas 37.2% in the control group (p=0.030, adj.p=0.360). Blood type 0 Rh (+) was significantly higher in the control group (p<0.001, adj.p<0.001).
Conclusion: These data suggest that individuals with blood type A are more directly related with insulin resistance, while those with type O are less directly related with insulin resistance in Turkish population.
insulin resistance, ABO blood subgroups, Rh system, HOMA-IR.