a,bThe First Clinical Medicine College of Lanzhou University, Lanzhou, China - bThe Second Hospital of Gansu Province, Lanzhou, China - cThe Hospital of Gansu Province, Lanzhou, China - dEvidence-Based Medicine Center, School of Basic Sciences, Lanzhou University, Lanzhou, China - eThe College of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, China


Objective: To determine more precise estimations for the relationship between TNF-a-308 polymorphism and the risk for HCC through a meta-analysis of the available data.

Materials and methods: We conducted a search for case-control studies on the association of TNF-a-308 polymorphism with susceptibility to HCC in PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, Embase, Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CJFD) and Wanfang Database. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to estimate the strength of the association between TNF- a-308 polymorphism and the risk for HCC.

Results: 24 studies were identified, including 4,331 HCC patients and 7,254 controls. Our results demonstrated a significant association between TNF-a-308 polymorphism and HCC risk in all genetic models while the control group was HCC-free. Howeve, when removing the data about healthy control, the pooled ORs were significantly decreased in the additive model (AA versus GG) and the allele model (G versus A), even no significant differences were observed in the rest genetic models. In an analysis stratified by ethnicity, increased risks were observed in both Asian and Caucasian populations.

Conclusion: This meta-analysis suggests that TNF-α-308 GG genotype might decrease the risk of HCC development, specifically among both Asian and Caucasian populations. However, these results should be interpreted with caution because of heterogeneity of control populations. Well-designed studies with appropriate controls, larger sample sizes and more in-depth data are required to confirm this conclusion.


HCC;TNF-alpha, polymorphism, meta-analysis