Authors

AGOSTINO SERRA, LUIGI MAIOLINO, GIANLUCA CAMPIONE, ANGELO CONTI, PAOLA DI MAURO        

Departments

ENT Department -University of Catania, Italy

Abstract

Introduction: Oxidative stress is a biological condition characterized by the breakdown of the physiological cellular balance between production and elimination of chemical elements for oxidizing activity.

Many causes may cause an increase in the production of free radicals of oxygen and the present study aims to assess the extent of oxidative stress, in patients undergoing surgical interventions in the ent district

Materials and methods: The study was performed on 50 patients, of both sexes, aged between 20 and 60 years, divided into two groups, A and B

The subjects in both groups had undergone surgery of various types within the ENT.

Group A consisted of 25 patients who, in the post-operative period for a total temporal space of 3 months, were treated with a compound with immunostimulatory activity, Pidotimod, while the B group, the control group, was composed of 25 patients who, in the post-operative period, were not treated with Pidotimod or other substances having immunostimulatory and/or bioprotective.

Each patient, either in group A and group B, was submitted to blood sampling for dosage of plasma levels and lymphocyte of specific markers of cellular oxidative stress,

Results: The analysis of the results has allowed us to notice Group A patients treated with Pidotimod, the presence of a whole set of variations lymphocyte and plasma between the two different phases, pre-and post-treatment

Conclusions: It is possible to state that patients undergoing surgery for otolaryngologic pathologies may be in systemic "oxidative stress" conditions.

Keywords

oxidative stress, surgical intervention, immunostimolatory activity, lymphocyte, plasma

DOI:

10.19193/0393-6384_2017_6_164