Authors

HATICE KARAGOZ1, ABDULSAMET ERDEN2, OZERHAN OZER2, ALI CETINKAYA2, DENIZ AVCI2, VEDAT GENCER2, FERHAT ARIK2, UGUR KALAN2, HASAN GORKEM2, HATICE KARAMAN3, AHMET KARAMAN1

Departments

1Acibadem Kayseri Hospital, Internal Medicine Department, Kayseri, Turkey - 2Kayseri Training and Research Hospital, Internal Medicine Department, Kayseri, Turkey - 3Kayseri Training and Research Hospital, Clinical Pathology Department, Kayseri, Turkey 

Abstract

Introduction: Non-alcoholic fatty liver disease is defined as the accumulation of fat in the liver in the absence of excessive alcohol consumption or other known pathologies and is a spectrum of disease ranging from steatosis (fat infiltration into the liver) to steatohepatitis. Non-alcoholic steatohepatitis is a more severe form of Non-alcoholic fatty liver disease which is characterised by stea- tosis, lobular inflammation, ballooning, and fibrosis in liver biopsies. In this study, we aimed to investigate any possible relationship between the ABO/Rh blood group system and Non-alcoholic fatty liver disease / Non-alcoholic steatohepatitis, in Turkey.

Materials and methods: A total of 179 patients with hepatosteatosis from Kayseri Training and Research Hospital between the years 2002-2012 were included in the study. The distributions of blood groups of the patients with Non-alcoholic fatty liver disease were compared with the distribution of blood groups of 17.314 healthy donors. The patients were examined for any association between ABO/Rh blood groups and Non-alcoholic fatty liver disease / Non-alcoholic steatohepatitis, and also for an association between ABO/Rh blood groups and grading.

Results: Group AB was found to be higher in patients with Non-alcoholic fatty liver disease compared to the control group (p=0.04). The percentage of patients with steatohepatitis was significantly higher in group AB than non-AB blood group (p=0.024). The percentage of patients with steatohepatitis was significantly higher in group grade 3 Non-alcoholic fatty liver disease patients than other two -grade 1 and grade 2 Non-alcoholic fatty liver disease - groups (<0.001).

Conclusion: To our knowledge, this is the first analysis in the literature that investigates the association between the ABO blood groups and Non-alcoholic fatty liver disease / Non-alcoholic steatohepatitis. This epidemiological study can not explain the mechani- sm behind the blood group effect but may be a light for future studies. 

Keywords

ABO, Blood Groups, Non-alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis.

DOI:

10.19193/0393-6384_2017_2_030