RAHIME KOCA1, METE EYIGOR2, USTUN OSMA1, HULYA EYIGOR2, MUSTAFA DENIZ YILMAZ1, OMER TARIK SELCUK1, LEVENT
RENDA1, MERAL GULTEKIN2
1Antalya Education and Research Hospital, Department of ENT Head and Neck Surgery, Antalya, Turkey - 2Akdeniz University Medical Faculty, Department of Medical Microbiology, Antalya, Turkey
Introduction: Several previous studies have investigated the significance of interleukin 17 (IL-17) in the pathogenesis of chronic rhinosinusitis with nasal polyposis; however, the importance of IL-23 has not been studied. We investigated the significance of IL-17 and IL-23 in the pathogenesis of by chronic rhinosinusitis with nasal polyposis measuring the levels of these proinflammatory cytoki- nes in serum and nasal lavage samples.
Materials and methods: Twenty-five patients aged >18 years with chronic rhinosinusitis with nasal polyposis and a control group with 25 healthy subjects were included the study. The levels of IL-17 and IL-23 were measured in the serum and nasal lavage fluids using enzyme-linked immunosorbent assays.
Results: The average serum level of IL-17 was 10.2 pg/ml in the study group, and it was 5.0 pg/ml in the control group. The ave- rage nasal lavage level of IL-17 was 16.8 pg/ml in the study group compared with 1.0 pg/ml in the control group. There were no stati- stically significant differences between the groups in the serum levels of IL-17 or IL-23; however, a significant difference between the two groups was found in the lavage fluid levels of IL-17 (p <0.001).
Conclusion: We found a significant difference in the nasal lavage fluid levels of IL-17, which demonstrates the importance of local inflammation. This supports the hypothesis that IL-17 is significant in the pathogenesis of nasal polyposis.
Chronic rhinosinusitis, nasal polyposis, IL-17A, IL-23, serum, nasal lavage, ELISA.