Authors

TURAN AKTAŞ*, FATMA AKTAŞ**, CANSEL ÖZMEN***, ZAFER ÖZMEN****, TURAN KAYA*****, OSMAN DEMIR******

Departments

*Pulmonar Medicine Department, Gaziosmanpaşa University School of Medicine, Tokat,Turkey - **Radiology Department, Gaziosmanpaşa University School of Medicine, Tokat, Turkey - ***Clinical Biochemistry Department , Gaziosmanpaşa University School of Medicine, Tokat, Turkey - ****Radiology Department , Gaziosmanpaşa University School of Medicine, Tokat, Turkey - *****Infections and Clinical Microbiology Department , Tokat State Hospital, Tokat, Turkey - ******Statistics Department , Gaziosmanpaşa University School of Medicine, Tokat, Turkey 

Abstract

Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonotic disease caused by infection with Nairoviruses in the Bunyaviridae family. The virus is transmitted to people by vectors such as ticks. Despite how little is known about the disease's pathophysiology, management of the clinical period, and developments in treatment, it is known that proinflammatory parameters and cytokines are important in the pathophysiology and clinical follow-up of viral hemorrhagic diseases with fever. Among these, the num- ber of platelets, neutrophils, and lymphocytes is important in diagnosis and clinical follow-up. There is a lot of information concerning how low platelet number is directly related to mortality and survival. Mean platelet volume (MPV) is a parameter showing platelet activation and function; therefore, it is a significant finding showing platelet maturation. For that reason, it can be claimed that plate- let activation plays an important role in CCHF.

Materials and methods: A total of 209 patients who were diagnosed as CCHF between May 2010 and September 2015 and whose lungs were examined during admission were retrospectively involved in the study. The patients’ demographic features, clinical findings and follow-ups, laboratory findings, radiological examinations of lung, and surveys were retrospectively examined.

Results: The 209 cases involved in the study consisted of 127 male (60.8%) and 82 female (39.2%) patients. Mean age was as 52 ± 18 years. Ferritin, procalcitonin, and CRP, which are related to inflammation, were high compared to the normal reference range, too. Mean platelets and leukocytes in hemogram were 56.200/μL ± 44.800 and 3.070/μL ± 2.930, respectively. Average MPV values in nonsurvival and survival groups were 11.50 fL ± 2.74 fL and 10.44 fL ± 2.40 fL, respectively.

Conclusions: The comparison of MPV between the survival and nonsurvival groups was found to be statistically significant (p<0.05) in CCHF. MPV can be used as a new and important clinical follow-up parameter for clinical observation of patients diagno- sed with CCHF in terms of both survival and radiological findings. 

Keywords

Crimean-Congo Hemorrhagic Fever, Mean Platelet Volume, Chest X-ray, Paranchymal Infiltration, Pleural Effusion.

DOI:

10.19193/0393-6384_2017_2_026