SHUXIN HOU, YINGMIN LU, DAMIN HUANG, XIAOHAN LUO, ZHAOXIA WANG, JINCHUN ZHANG, WEIPING XU
Department of Cardiology, XinHua (Chongming) Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai 202150, China
Background: This study aimed to investigate renin-angiotensin-aldosterone system gene polymorphism in atrial fibrillation (AF) patients.
Materials and methods: 82 AF patients diagnosed in this survey were included for investigation, and 82 subjects without AF served as controls.
Results: There were 3 genotypes of AGT M235T in the subjects investigated: MM genotype (7.32% vs. 13.41%), MT (26.83% vs. 35.37%) and TT (65.85% vs. 51.22%). The TT genotype frequency and T allele frequency in AF group were significantly higher than in control group (P<0.05). Logistic regression analysis showed T allele increased the risk for AF by 1.57 times (P<0.05). There were 3 genotypes of ACE AluI/D in the subjects investigated: II genotype (17.07% vs. 46.34%), ID genotype (51.22% vs. 34.15%) and DD genotype (31.71% vs. 19.51%). The DD genotype frequency and D allele frequency in AF group were markedly higher than in control group (P<0.05). Logistic regression analysis showed D allele increased the risk for AF by 2.42 folds (OR=2.42, P<0.05). CYP112B2- 344C/T showed TT, TC and CC genotypes, and their frequencies were 64.63%, 25.61% and 9.76%, respectively in AF group and 58.54%, 29.27% and 12.20%, respectively in control group. Allele T frequency was 77.44% and 73.17% in AF group and control group, respectively, and allele C frequency was 22.56% and 26.83% in AF group and control group, respectively. No significant diffe- rences were observed in the allele C and T frequencies between two groups (P>0.05). CYP112B2-344C/T gene polymorphism had no relationship with AF.
Conclusion: In AF adults of Chongming, AGT-M235T, angiotensin converting enzyme (ACE) AluI/D and CYP112B2 -344C/T genes show polymorphisms, T allele of AGT- M235T gene and D allele of ACE AluI/D gene may increase the risk for AF, and CYP112B2-344C/T gene polymorphism has no relationship with AF.
Atrial fibrillation; renin-angiotensin-aldosterone system; gene polymorphism.