Authors

MOHAMMAD REZA MIRJALILI*, FAKHRADDIN SHIRANIAN**, MASOUD RAHIMIAN***, LALEH BORJIAN****, ALI DEH- GHANI*****

Departments

*Department of Internal medicine, ShahidSadoughi University of Medical Sciences, Yazd, Iran - **Internal medicine specialist, ShahidSadoughi University of Medical Sciences, Yazd, Iran - ***Department of Internal medicine, ShahidSadoughi University of Medical Sciences, Yazd, Iran - ****MD, Hospital Management Research Center, ShahidSadoughi University of Medical Sciences, Yazd, Iran - *****Assisstant professor, Biostatistic and epidemiology Department, ShahidSadoughi University of Medical Sciences, Yazd, Iran

Abstract

Introduction: Statins are basically used for hyperlipidemia therapy, but also may be useful for protection from cardiovascular events. In addition, there is increasing evidence for the potential positive effect of statin therapy on the outcome of patients with sepsis.

Material and methods: In a randomized double blinded clinical trial, we evaluated 60 patients aged 18-85 with confirmed sepsis.We evaluated APACHE ІІ score and all-cause mortality as outcome predictors.

Results: The APACHE score in days1 and 3 was not significantly different between two groups, but in day 7 it was significantly higher in group B than group A. Survival after one month ( mean ±95% CI ) also had not significant differences. The number needed to treat ( NNT) was 5.

Conclusion: The mainstem of the studies suggest that statins may have a positive effect on the outcome of patients with sepsis. However, the majority of the available studies had the inherent methodological flaws of retrospective design. We concluded that regarding present evidence, clinician should wait for the results of ongoing relevant randomized controlled trials.

Keywords

The APACHE score,Simvastatin, Sepsis, RCT