Authors

BEHNAMIPOUR S1,2, ABBASI KH3, ROUHOLLAHI A3, MAZLOUM ARDAKANI M4, HAGHGOO S5, ARAST Y6

Departments

1 MSc of Analytical Chemistry, School of Health, Qom University of Medical Sciences, Qom, Iran - 2 Department of Chemistry, Payame Noor University (PNU), Ardakan, Iran - 3 Department of Chemistry, Faculty of Science, K.N. Toosi University of Technology, Tehran, Iran - 4 Department of Chemistry, Faculty of Science, Yazd University, I.R. Iran - 5 Pharmaceutical Department, Food & Drug Laboratory Research Center, Food & Drug Organization (FDO), Ministry of Health - 6 PhD Candidate, Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Tuberculosis is a contagious disease, this disease in third world countries of health problems. Isoniazid is an antituberculosis agent, which is now widely used together with other anti tuberculostatic agents for chemotherapy of tuberculosis. In this study, the investigations were performed by using cyclic voltammetry method on modified glassy carbon electrode with ionic liquid 1-Hexyl-3- methylimidazolium bis (trifluoromethylsulfonyl) amide [Hmim] [NTF2] and the thickness of gel on surface of electrode was optimized by anodic peak current. Also another effective factor such as pH effect, continuous scans effect and scan rate effect was studied. The results show that carbon ionic liquid electrode (CILE) reduces the overpotential of INZ oxidation, without showing any fouling effect due to the deposition of their oxidized products, In the case of INZ, the oxidation peak potentials appear at 1022 mV (vs Ag/AgCl, KCl, 3.0M), respectively, and the carbon ionic liquid electrode (CILE) shows a significantly better reversibility for isoniazid. Differential pulse voltammetry was used for the determination INZ. Relative standard deviation for INZ was less than 3%.

Keywords

Tuberculosis, Carbon ionic liquid electrode, Isoniazid, Cyclic voltammetry, [Hmim] [NTF2]