Authors

SEYED MEHDI HASHEMI1, ZAHRA ZAKERI2, FARZANEH KHADEM SAMENI3*, ABOLGHASEM ALLAHYARI4, ALIREZA ANSARIMOGHADDAM5

Departments

1 Assistant Professor of Hematology and Medical Oncology, Internal Ward-Hematology and Medical Oncology Part-Ali-EbneAbitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran - 2 Associate professor of Rheumatology, department of internal medicine, school of medicine, Shahid Behshti university of medical sciences, Tehran, Iran - 3 Dr. Farzaneh Khadem Sameni, MD- Pathologist, Assistant Professor, Faculty of Medicine, Islamic Azad University, Zahedan branch, Iran - 4 Assistant professor of hematology and medical oncology, department of medicine, school of medicine, university of Mashhad, Mashhad, Iran - 5 Health promotion research center, Zahedan university of medical sciences, zahedan, Iran

Abstract

Aim: The purpose of this study is to measure changes in bone density caused by chemotherapy in patients with breast cancer.

Materials and methods: This was a cohort study on 72 pre-menopausal patients with breast cancer selected by convenient sampling from public and private hematology and medical oncology clinics in Zahedan during 2012-2015. The bone density was measured before chemotherapy and 6 months after receiving chemotherapy by DXA in femur and vertebrae L1-L4. The results of prechemotherapy bone density were compared to post-chemotherapy results (after 6 months) using t-paired test.

Results: Findings showed that the lumbar BMD was 0.97 ± 0.11 before receiving chemotherapy and 0.92 ± 0.11 after 6 months of chemotherapy, which indicates a significant difference (P= <0.001). moreover, femoral BMD was 0.88 ± 0.31 before receiving chemotherapy and 0.82 ± 0.12 after 6 months of chemotherapy, which indicates a significant difference (P= <0.001).

Discussion and Conclusion: In this study, bone density generally decreased in the femoral neck and lumbar spine in patients with breast cancer treated with chemotherapy. Furthermore, a relationship was found between the received chemotherapy regimen and the reduced chance of developing bone density.

Keywords

chemotherapy, bone density, breast cancer