Authors

FARNAZ FARIBA1*, FARZANEH MAHBOOBIAN2

Departments

1 Department of cardiology, Farshchian Hospital, University of Hamedan, Hamedan, Iran - 2 Department of cardiology, Farshchian Hospital, University of Hamedan, Hamedan, Iran

Abstract

Purpose and background: Ischemic heart diseases (IHDs) occurring as a result of the lack of adequate supply of blood and oxygen to part of the myocardium, are the most common causes of death and disability in developed countries. Since platelets play a fundamental role in the onset of atherosclerosis and coronary clots, assessment of platelet volume indices (PVI) can be important in the prediction and detection of coronary facts. This research was conducted to compare the Mean Platelet Volume (MPV) between patients with myocardial infarction (MI) and healthy individuals.

Materials and methods: The study population in this cross-sectional survey included 36 patients with acute myocardial infarction (AMI) and 36 healthy individuals whose PVIs were compared with each other. After questioning and recording the demographic data of both groups, their blood samples were taken for testing the platelet indices and the results for the MPV were registered in a questionnaire and analyzed using the SPSS software.

Findings: the mean and standard deviation for the platelet volume (PV) in patients with AMI and healthy individuals (control group) were┬▒ 0.95, 10.01 and ┬▒0.29, 9.07, respectively. The mean difference in the PV between the two groups was statistically significant (P.value = 0.000). No significant difference was observed between the MPV and the variables of age and gender. Also, no significant differences were observed between the MPV and risk factors for high blood pressure, diabetes, cigarette smoking and body mass index (BMI).

Conclusion: This study showed that the MPV is clinically important and a high level of this index can independently be considered as a prognostic factor for cardiovascular disease and myocardial infarction.

Keywords

acute myocardial infarction (AMI), mean platelet volume (MPV), coronary artery disease (CAD), prognostic factor.