SEYED HOJJAT HOSSEINI*1, HAMID REZA ESHRAGHI1, MEHRDAD HAMIDI2
Department of Veterinary basic science, Science and Research branch, Islamic Azad University, Tehran, Iran -
Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, Iran
The aim of the present study was to evaluate the anti-inflammatory ability of liposomal prednisolone in a carrageenan induced
acute inflammatory paw edema model. Drug delivery to inflammatory tissue via liposomal nanoparticles may improve therapeutic
agents’ risk-benefit ratios. prednisolone encapsulated in long-circulating liposomes can inhibit inflammation after administration.
The mechanism by which liposomal prednisolone inhibits Production of inflammatory factor. Variable efficacies have been reported
for prednisolone drugs as anti-inflammatory treatment. Liposomal prednisolone was administered to male Wistar rats. carrageenan
at a concentration of 1% was injected into hind paw of rats. The thickness of paws was measured by caliper within 0, 1, 2, 3, and 4
hours after the injections to confirm the inflammation. Blood samples were collected immediately after carrageenan injection and
also 12 h thereafter. The sera were separated for measurements of interleukin 6 (IL-6). The prednisolone and liposomal prednisolone
are efficacious in controlling the paw sizes, as indicators of inflammation; the liposomal prednisolone is remarkably more effective in
controlling the inflammation in long term. Both the drug forms were clearly efficient in lowering the IL-6 level. Mostly noteworthy,
the liposomal prednisolone was remarkably more efficient in lowering IL-6 levels.
liposomal, long circulation, Inflammation, Interleukin 6